Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Passage‐dependent cancerous transformation of human mesenchymal stem cells under carcinogenic hypoxia

8 Apr 2013

Abstract excerpt

Bone marrow-derived human mesenchymal stem cells (hMSCs) either promote or inhibit cancer progression, depending on factors that heretofore have been undefined. Here we have utilized extreme hypoxia (0.5% O2) and concurrent treatment with metal carcinogen (nickel) to evaluate the passage-dependent response of hMSCs toward cancerous transformation. Effects of hypoxia and nickel treatment on hMSC proliferation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Mesenchymal stem cell research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23568779
DOI: 10.1096/fj.13-228288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Passage‐dependent cancerous transformation of human mesenchymal stem cells under carcinogenic hypoxiaPMID 23568779Read ↗

Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cellsSemantic proximity Read ↗

Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cellsSemantic proximity Read ↗

Cancer Stem-Like Cells Accumulated in Nickel-Induced Malignant Transformation.Semantic proximity Read ↗

Chronic Hexavalent Chromium Exposure Induces Cancer Stem Cell-Like Property and Tumorigenesis by Increasing c-Myc ExpressionSemantic proximity Read ↗

Chronic inorganic arsenic exposure in vitro induces a cancer cell phenotype in human peripheral lung epithelial cells.Semantic proximity Read ↗

Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancerSemantic proximity Read ↗

Immortalization without neoplastic transformation of human mesenchymal stem cells by transduction with HPV16 E6/E7 genes.Semantic proximity Read ↗

Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cellsSemantic proximity Read ↗

Epigenetic mechanisms of nickel carcinogenesis.Semantic proximity Read ↗

Chronic nickel (II) exposure induces the stemness properties of cancer cells through repressing isocitrate dehydrogenase (IDH1).Semantic proximity Read ↗

Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation.Semantic proximity Read ↗

Analysis of the multistep process of carcinogenesis using human fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.