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Article

Activin Inhibits the Human Pit-1 Gene Promoter through the p38 Kinase Pathway in a Smad-Independent Manner

2 Jun 2006

Abstract excerpt

The pituitary transcription factor Pit-1 regulates hormonal production from the anterior pituitary gland. However, the mechanisms by which Pit-1 gene expression is regulated in humans are poorly understood. Activin, a member of the TGFbeta superfamily, acts as a negative regulator of cell growth and prolactin gene expression in lactotrope cells. In this study, we show that activin negatively regulates the human...

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PMID: 16740974
DOI: 10.1210/en.2006-0444

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Activin Inhibits the Human Pit-1 Gene Promoter through the p38 Kinase Pathway in a Smad-Independent MannerPMID 16740974Read ↗

Basic science and clinical research advances in the pituitary transcription factors: Pit-1 and Prop-1.Semantic proximity Read ↗

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