Article
Association of the CPT1B gene with skeletal muscle fat infiltration in Afro-Caribbean men.
Obesity (Silver Spring, Md.) - 1 Jul 2009
Miljkovic Iva, Yerges Laura M, Li Hu, Gordon Christopher L, Goodpaster Bret H, Kuller Lewis H, Nestlerode Cara S, Bunker Clareann H, Patrick Alan L, Wheeler Victor W, Zmuda Joseph M
Abstract excerpt
Skeletal muscle fat is greater in African ancestry individuals compared with whites, is associated with diabetes, and is a heritable polygenic trait. However, specific genetic factors contributing to skeletal muscle fat in humans remain to be defined. Muscle carnitine palmitoyltransferase-1B (CPT1B) is a key enzyme in the regulation of skeletal muscle mitochondrial beta-oxidation of long-chain fatty acids, and as...
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