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Article

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations.

Brain : a journal of neurology - 1 Mar 2010

Abramov Andrey Y, Smulders-Srinivasan Tora K, Kirby Denise M, Acin-Perez Rebeca, Enriquez José Antonio, Lightowlers Robert N, Duchen Michael R, Turnbull Douglass M

Abstract excerpt

Mutations of mitochondrial DNA are associated with a wide spectrum of disorders, primarily affecting the central nervous system and muscle function. The specific consequences of mitochondrial DNA mutations for neuronal pathophysiology are not understood. In order to explore the impact of mitochondrial mutations on neuronal biochemistry and physiology, we have used fluorescence imaging techniques to examine...

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Identifiers

PMID: 20157008
DOI: 10.1093/brain/awq015
PMCID: PMC2842515

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