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Article

Frequent epigenetic inactivation of the SLIT2 gene in chronic and acute lymphocytic leukemia

16 May 2009

Abstract excerpt

Recently a mouse model of T/natural killer acute lymphoblastic leukemia was used to assess global promoter methylation across the mouse genome using the restriction landmark genomic scanning technique. One of the methylated mouse genes identified in this way was Slit2. There are three mammalian SLIT genes (SLIT1, SLIT2, SLIT3), that belong to a highly conserved family of axon guidance molecules. We have...

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Share to Acute Lymphoblastic Leukemia research
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PMID: 19550140
DOI: 10.4161/epi.9137

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