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Article

SLIT2 promoter methylation analysis in neuroblastoma, Wilms' tumour and renal cell carcinoma

1 Jan 2004

Abstract excerpt

The 3p21.3 RASSF1A tumour suppressor gene (TSG) provides a paradigm for TSGs inactivated by promoter methylation rather than somatic mutations. Recently, we identified frequent promoter methylation without somatic mutations of SLIT2 in lung and breast cancers, suggesting similarities between SLIT2 and RASSF1A TSGs. Epigenetic inactivation of RASSF1A was first described in lung and breast cancers and subsequently...

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PMID: 14735202
DOI: 10.1038/sj.bjc.6601447

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