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Article

Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease.

Cancer research - 1 Jul 2009

Di Vizio Dolores, Kim Jayoung, Hager Martin H, Morello Matteo, Yang Wei, Lafargue Christopher J, True Lawrence D, Rubin Mark A, Adam Rosalyn M, Beroukhim Rameen, Demichelis Francesca, Freeman Michael R

Abstract excerpt

Oncosomes have recently been described as membrane-derived microvesicles secreted by cancer cells, which transfer oncogenic signals and protein complexes across cell boundaries. Here, we show the rapid formation and secretion of oncosomes from DU145 and LNCaP human prostate cancer cells. Oncosome formation was stimulated by epidermal growth factor receptor activation and also by overexpression of...

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Identifiers

PMID: 19549916
DOI: 10.1158/0008-5472.CAN-08-3860
PMCID: PMC2853876

Genes

DIAPH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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