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Article

JAK/STAT blockade reverses the malignant phenotype of Hodgkin and Reed-Sternberg cells.

Blood advances - 8 Aug 2023

Fernández Sara, Solórzano Jose L, Díaz Eva, Menéndez Victoria, Maestre Lorena, Palacios Sara, López Mar, Colmenero Argentina, Estévez Mónica, Montalbán Carlos, Martínez Ángel, Roncador Giovanna, García Juan F

Abstract excerpt

Constitutive activation of the JAK/STAT pathway is a common phenomenon in classic Hodgkin lymphoma (cHL). The clinical potential of anti-JAK/STAT therapy is being explored in early-stage clinical trials. Notwithstanding, very little information is available about the complex biological consequences of this blockade. Here, we investigated the effects of JAK/STAT pharmacological inhibition on cHL cell models using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36459489
DOI: 10.1182/bloodadvances.2021006336
PMCID: PMC10407154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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