Article
Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1.
Cancer research - 1 Jul 2009
Goel Hira Lal, Moro Loredana, Murphy-Ullrich Joanne E, Hsieh Chung-Cheng, Wu Chin-Lee, Jiang Zhong, Languino Lucia R
Abstract excerpt
Beta(1) integrins play an important role in regulating cell proliferation and survival. Using small interfering RNA or an inhibitory antibody to beta(1), we show here that, in vivo, beta(1) integrins are essential for prostate cancer growth. Among the five known beta(1) integrin cytoplasmic variants, two have been shown to differentially affect prostate cell functions. The beta(1A) variant promotes normal and...
Topics
- Animals
- Apoptosis
- Cell Division
- Endothelial Cells
- Endothelium, Vascular
- Extracellular Matrix Proteins
- Gene Expression Regulation
- Genetic Variation
- Humans
- Integrin beta1
- Male
- Mice
- Mice, Transgenic