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Article

Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation.

Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2010

Fitchev Philip P, Wcislak Susan M, Lee Chung, Bergh Anders, Brendler Charles B, Stellmach Veronica M, Crawford Susan E, Mavroudis Constantine D, Cornwell Mona L, Doll Jennifer A

Abstract excerpt

Castration experiments in rodents show that the stromal vasculature is critical to the androgen-mediated prostate growth regulation. However, the role of angiogenesis inhibitors, such as thrombospondin-1 (TSP-1), in this process is unclear. TSP-1 is a multifunctional glycoprotein that can functio...

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Identifiers

PMID: 20458281
DOI: 10.1038/labinvest.2010.90
PMCID: PMC3055786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20458281-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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