Article
Regulation of mRNA and protein levels of beta1 integrin variants in human prostate carcinoma.
The American journal of pathology - 1 Nov 2000
Perlino E, Lovecchio M, Vacca R A, Fornaro M, Moro L, Ditonno P, Battaglia M, Selvaggi F P, Mastropasqua M G, Bufo P, Languino L R
Abstract excerpt
Alterations of integrin expression levels in cancer cells correlate with changes in invasiveness, tumor progression, and metastatic potential. The beta1C integrin, an alternatively spliced form of the human beta1 integrin, has been shown to inhibit prostate cell proliferation. Furthermore, beta1C protein levels were found to be abundant in normal prostate glandular epithelium and down-regulated in prostatic...
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