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Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth

27 Mar 2019

Abstract excerpt

The β1 integrins, known to promote cancer progression, are abundant in extracellular vesicles (EVs). We investigated whether prostate cancer (PrCa) EVs affect anchorage-independent growth and whether β1 integrins are required for this effect. Specifically using a cell-line-based genetic rescue and an in vivo PrCa model, we show that gradient-purified small EVs (sEVs) from either cancer cells or blood from...

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PMID: 30981115
DOI: 10.1016/j.isci.2019.03.022

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