Article
Transcriptional regulation of the beta1C integrin splice variant in human prostate adenocarcinoma.
International journal of oncology - 1 Dec 2003
Moro Loredana, Greco Margherita, Ditonno Pasquale, Battaglia Michele, Marra Ersilia, Perlino Elda
Abstract excerpt
Members of the integrin family of cell adhesion receptors influence several important aspects of cancer cell behaviour, including motility and invasiveness, cell growth and cell survival. beta1C integrin, an alternatively spliced variant of the human beta1 integrin, has been shown to inhibit cell proliferation. We have previously demonstrated that beta1C integrin mRNA and protein are present in normal prostate...
Topics
- Aged
- Alternative Splicing
- Blotting, Northern
- Cell Adhesion
- Cell Nucleus
- Cytoplasm
- Genetic Variation
- Humans
- Integrin beta1
- Male
- Middle Aged
- Prostate
- Prostatic Neoplasms
- RNA
- RNA, Messenger
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription, Genetic
