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Article

A dual-fluorescence high-throughput cell line system for probing multidrug resistance.

Assay and drug development technologies - 1 Jun 2009

Brimacombe Kyle R, Hall Matthew D, Auld Douglas S, Inglese James, Austin Christopher P, Gottesman Michael M, Fung King-Leung

Abstract excerpt

The efflux pump P-glycoprotein (ATP-binding cassette B1, multidrug resistance [MDR] 1, P-gp) has long been known to contribute to MDR against cancer chemotherapeutics. We describe the development of a dual-fluorescent cell line system to allow multiplexing of drug-sensitive and P-gp-mediated MDR cell lines. The parental OVCAR-8 human ovarian carcinoma cell line and the isogenic MDR NCI/ADR-RES subline, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19548831
DOI: 10.1089/adt.2008.165
PMCID: PMC2814070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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