Article
Synergistic effect of HLA class II loci and cytokine gene polymorphisms on the risk of gastric cancer in Japanese patients with Helicobacter pylori infection.
International journal of cancer - 1 Dec 2009
Ando Takashi, Ishikawa Takeshi, Kato Haruki, Yoshida Norimasa, Naito Yuji, Kokura Satoshi, Yagi Nobuaki, Takagi Tomohisa, Handa Osamu, Kitawaki Jo, Nakamura Naoto, Hasegawa Goji, Fukui Michiaki, Imamoto Eiko, Nakamura Chie, Oyamada Hirokazu, Isozaki Yutaka, Matsumoto Naohito, Nagao Yasuyuki, Okita Mika, Nakajima Yoshihiro, Kurokawa Manabu, Nukina Masafumi, Ohta Mitsuhiro, Mizuno Shigeto, Ogata Masakazu, Obayashi Hiroshi, Park Hyohun, Kitagawa Yoshihiro, Nakano Koji, Yoshikawa Toshikazu
Abstract excerpt
It has been reported that polymorphisms of human leukocyte antigen (HLA) genes and several cytokine genes are associated with an increased risk of developing gastric cancer (GC). However, the results of studies from different geographic regions, ethnic groups and study groups are inconsistent. The aim of this study was to evaluate the influence of H. pylori infection and host genetic factors on GC susceptibility...
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