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Combination of Interleukin 1 Polymorphism and Helicobacter pylori Infection: an Increased Risk of Gastric Cancer in Pakistani Population.

Pathology oncology research : POR - 1 Oct 2017

Raza Yasir, Khan Adnan, Khan Asif Iqbal, Khan Saeed, Akhter Shakeel, Mubarak Muhammad, Ahmed Ayaz, Kazmi Shahana Urooj

Abstract excerpt

Helicobacter pylori is one of the major risk factors involved in the development ofgastritis and gastric cancer (GC). H. pylori infection leads to increased production of pro-inflammatory cytokines by the host. Carriage of specific polymorphisms in cytokine genes may be associated with host susceptibility to the development of GC. We investigated the role of host genetic factors including polymorphisms of IL-1B...

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PMID: 28110439
DOI: 10.1007/s12253-017-0191-9

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