Article
Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution.
Nature neuroscience - 1 Jul 2009
Kessels Helmut W, Kopec Charles D, Klein Matthew E, Malinow Roberto
Abstract excerpt
Understanding how the subcellular fate of newly synthesized AMPA receptors (AMPARs) is controlled is important for elucidating the mechanisms of neuronal function. We examined the effect of increased synthesis of AMPAR subunits on their subcellular distribution in rat hippocampal neurons. Virally expressed AMPAR subunits (GluR1 or GluR2) accumulated in cell bodies and replaced endogenous dendritic AMPAR with...
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