Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype.

doi:10.1093/ije/dyp162

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Article

Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype.

International journal of epidemiology - 1 Aug 2009

Brennan Paul, McKay James, Moore Lee, Zaridze David, Mukeria Anush, Szeszenia-Dabrowska Neonilia, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Mates Dana, Bencko Vladimir, Foretova Lenka, Janout Vladimir, Chow Wong-Ho, Rothman Nathaniel, Chabrier Amélie, Gaborieau Valérie, Timpson Nic, Hung Rayjean J, Smith George Davey

Abstract excerpt

BACKGROUND: Obesity is a risk factor for several cancers although appears to have an inverse association with cancers strongly related to tobacco. Studying obesity is difficult due to numerous biases and confounding. METHODS: To avoid these biases we used a Mendelian randomization approach incorporating an analysis of variants in the FTO gene that are strongly associated with BMI levels among 7000 subjects from a...

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PMID: 19542184
DOI: 10.1093/ije/dyp162
PMCID: PMC2734066

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