Article
Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study.
PloS one - 1 Jan 2017
Carreras-Torres Robert, Johansson Mattias, Haycock Philip C, Wade Kaitlin H, Relton Caroline L, Martin Richard M, Davey Smith George, Albanes Demetrius, Aldrich Melinda C, Andrew Angeline, Arnold Susanne M, Bickeböller Heike, Bojesen Stig E, Brunnström Hans, Manjer Jonas, Brüske Irene, Caporaso Neil E, Chen Chu, Christiani David C, Christian W Jay, Doherty Jennifer A, Duell Eric J, Field John K, Davies Michael P A, Marcus Michael W, Goodman Gary E, Grankvist Kjell, Haugen Aage, Hong Yun-Chul, Kiemeney Lambertus A, van der Heijden Erik H F M, Kraft Peter, Johansson Mikael B, Lam Stephen, Landi Maria Teresa, Lazarus Philip, Le Marchand Loïc, Liu Geoffrey, Melander Olle, Park Sungshim L, Rennert Gad, Risch Angela, Haura Eric B, Scelo Ghislaine, Zaridze David, Mukeriya Anush, Savić Milan, Lissowska Jolanta, Swiatkowska Beata, Janout Vladimir, Holcatova Ivana, Mates Dana, Schabath Matthew B, Shen Hongbing, Tardon Adonina, Teare M Dawn, Woll Penella, Tsao Ming-Sound, Wu Xifeng, Yuan Jian-Min, Hung Rayjean J, Amos Christopher I, McKay James, Brennan Paul
Abstract excerpt
BACKGROUND: Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer. METHODS AND FINDINGS: We identified genetic instruments for potential metabolic risk factors and evaluated these in...
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