Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men.

doi:10.1371/journal.pone.0004428

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Article

Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men.

PloS one - 1 Jan 2009

Zimmermann Esther, Kring Sofia I I, Berentzen Tina L, Holst Claus, Pers Tune H, Hansen Torben, Pedersen Oluf, Sørensen Thorkild I A, Jess Tine

Abstract excerpt

BACKGROUND: The A-allele of the single nucleotide polymorphism (SNP), rs9939609, in the FTO gene is associated with increased fatness. We hypothesized that the SNP is associated with morbidity and mortality through the effect on fatness. METHODOLOGY/PRINCIPAL FINDINGS: In a population of 362,200 Danish young men, examined for military service between 1943 and 1977, all obese (BMI>or=31.0 kg/m(2)) and a random 1%...

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PMID: 19214238
DOI: 10.1371/journal.pone.0004428
PMCID: PMC2639637

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