Article
Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization.
International journal of cancer - 1 Mar 2021
Zhou Wen, Liu Geoffrey, Hung Rayjean J, Haycock Philip C, Aldrich Melinda C, Andrew Angeline S, Arnold Susanne M, Bickeböller Heike, Bojesen Stig E, Brennan Paul, Brunnström Hans, Melander Olle, Caporaso Neil E, Landi Maria Teresa, Chen Chu, Goodman Gary E, Christiani David C, Cox Angela, Field John K, Johansson Mikael, Kiemeney Lambertus A, Lam Stephen, Lazarus Philip, Le Marchand Loïc, Rennert Gad, Risch Angela, Schabath Matthew B, Shete Sanjay S, Tardón Adonina, Zienolddiny Shanbeh, Shen Hongbing, Amos Christopher I
Abstract excerpt
At the time of cancer diagnosis, body mass index (BMI) is inversely correlated with lung cancer risk, which may reflect reverse causality and confounding due to smoking behavior. We used two-sample univariable and multivariable Mendelian randomization (MR) to estimate causal relationships of BMI and smoking behaviors on lung cancer and histological subtypes based on an aggregated genome-wide association studies...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.