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Article

Phosphorylation of human enhancer of filamentation (HEF1) on serine 369 induces its proteasomal degradation.

Biochemical pharmacology - 15 Oct 2009

Hivert Virginie, Pierre Josiane, Raingeaud Joël

Abstract excerpt

Human enhancer of filamentation 1 (HEF1) is a multi-domain docking protein of the p130 Cas family. HEF1 is present at focal adhesions and is involved in integrin signalling mediating cytoskeleton reorganization associated with cell migration, adhesion or apoptosis. HEF1 functions are regulated in part by phosphorylation on tyrosine residues. HEF1 is also phosphorylated on serines/threonines leading to two...

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PMID: 19539609
DOI: 10.1016/j.bcp.2009.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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