Article
Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn.
FEBS letters - 2 Jun 2000
Ishino M, Aoto H, Sasaski H, Suzuki R, Sasaki T
Abstract excerpt
Hic-5 is a CAKbeta-binding protein localized at focal adhesions. Here we show that overexpression of CAKbeta or Fyn, but not FAK, enhanced the tyrosine phosphorylation of coexpressed Hic-5 in COS-7 cells. These phosphorylations were further augmented by stimulating cells with osmotic stress. The Y60F mutant of Hic-5 was not phosphorylated, and Hic-5 phosphorylated on tyrosine 60 was bound specifically to the SH2...
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