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Article

Association of Filaggrin loss-of-function-mutations with atopic dermatitis and asthma in the Early Treatment of the Atopic Child (ETAC) population.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Jun 2009

Müller Sebastian, Marenholz Ingo, Lee Young-Ae, Sengler Claudia, Zitnik Simona Eva, Griffioen Rupino W, Meglio Paolo, Wahn Ulrich, Nickel Renate

Abstract excerpt

Many candidate gene studies for atopic dermatitis (AD) and associated phenotypes have been conducted so far, but replication of significant results has been a major problem. Two loss of function polymorphisms FLG R501X- and 2282del4, in the Filaggrin (FLG) gene encoding for an epidermal barrier protein were recently identified. They were reported to be predisposing factors for AD and concomitant asthma. Several...

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Identifiers

PMID: 19538357
DOI: 10.1111/j.1399-3038.2008.00808.x

Genes

FLG

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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