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Article

The novel "genomic pathway approach" to complex diseases: a reason for (over-)optimism?

Epidemiology (Cambridge, Mass.) - 1 Jul 2009

Breitling Lutz P, Steyerberg Ewout W, Brenner Hermann

Abstract excerpt

BACKGROUND: Examination of the genetic structure of complex diseases by a "genomic pathway approach"--which applies stepwise model selection to sets of more than 1000 polymorphisms in studies of several hundred subjects--has recently been proposed. Models constructed through extensive selection procedures may yield misleading test statistics and measures of predictive performance; we aimed to quantify the extent...

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PMID: 19533849
DOI: 10.1097/ede.0b013e3181a70acd

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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