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Overexpression of Bcl‐X<sub>L</sub> in human neural stem cells promotes graft survival and functional recovery following transplantation in spinal cord injury

15 Jun 2009

Abstract excerpt

Transplantation of neural stem cells (NSCs) has shown promise for improving functional recovery after spinal cord injury (SCI). The inhospitable milieu of injured spinal cord, however, does not support survival of grafted NSCs, reducing therapeutic efficacy of transplantation. The present study sought to examine whether overexpression of antiapoptotic gene Bcl-X(L) in NSCs could promote graft survival and...

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Share to Nerve injury and regeneration
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PMID: 19530162
DOI: 10.1002/jnr.22149

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