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A novel mutation in pmrB mediates colistin resistance during therapy of Acinetobacter baumannii.

International journal of antimicrobial agents - 1 Jun 2017

Dahdouh Elias, Gómez-Gil Rosa, Sanz Sonia, González-Zorn Bruno, Daoud Ziad, Mingorance Jesús, Suárez Monica

Abstract excerpt

Acinetobacter baumannii is a highly versatile nosocomial pathogen. Multidrug resistance among A. baumannii isolates led to the use of colistin, subsequently giving rise to colistin-resistant strains. In this study, the genetic and phenotypic profiles of two colistin-resistant A. baumannii isolates were investigated. Two A. baumannii isolates were obtained from Patient 1 (C071 and C440) and three isolates were...

Topics

Acinetobacter Infections
Acinetobacter baumannii
Anti-Bacterial Agents
Bacterial Proteins
Colistin
Drug Resistance, Bacterial
Humans
Microbial Sensitivity Tests
Molecular Typing
Multiplex Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Random Amplified Polymorphic DNA Technique

Transcription Factors

Virulence

beta-Lactamases

Source

Identifiers

PMID: 28438568
DOI: 10.1016/j.ijantimicag.2017.01.031

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