Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fine mapping of gene regions regulating neurodegeneration.

PloS one - 15 Jun 2009

Swanberg Maria, Harnesk Karin, Ström Mikael, Diez Margarita, Lidman Olle, Piehl Fredrik

Abstract excerpt

BACKGROUND: Damage to nerve cells and axons leading to neurodegeneration is a characteristic feature of many neurological diseases. The degree of genetic influence on susceptibility to axotomy-induced neuronal death has so far been unknown. We have examined two gene regions, Vra1 and Vra2, previously linked to nerve cell loss after ventral root avulsion in a rat F2 intercross between the DA and PVG inbred rat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Chromosome Mapping
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Haplotypes

Share to Neurodegenerative Diseases

Share to Spinal Cord

Source

Open in PubMed Open full text

Identifiers

PMID: 19526058
DOI: 10.1371/journal.pone.0005906
PMCID: PMC2691596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fine mapping of gene regions regulating neurodegeneration.PMID 19526058Read ↗

Naturally occurring genetic variability in expression of Gsta4 is associated with differential survival of axotomized rat motoneurons.Semantic proximity Read ↗

The axon reaction: identifying the genes that make a difference.Semantic proximity Read ↗

Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS.Semantic proximity Read ↗

CNS repair and axon regeneration: Using genetic variation to determine mechanisms.Semantic proximity Read ↗

Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse.Semantic proximity Read ↗

A null mutation in VAMP1/synaptobrevin is associated with neurological defects and prewean mortality in the lethal-wasting mouse mutant.Semantic proximity Read ↗

hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the neuromuscular junctionSemantic proximity Read ↗

The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression.Semantic proximity Read ↗

A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes.Semantic proximity Read ↗

Astrocytic Expression of GSTA4 Is Associated to Dopaminergic Neuroprotection in a Rat 6-OHDA Model of Parkinson’s DiseaseSemantic proximity Read ↗

A cross-species approach using an <i>in vivo</i> evaluation platform in mice demonstrates that sequence variation in the human <i>RABEP2</i> gene modulates ischemic stroke outcomesSemantic proximity Read ↗

A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.