Article
The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression.
Neuron - 1 May 1997
Hamilton B A, Smith D J, Mueller K L, Kerrebrock A W, Bronson R T, van Berkel V, Daly M J, Kruglyak L, Reeve M P, Nemhauser J L, Hawkins T L, Rubin E M, Lander E S
Abstract excerpt
The mouse vibrator mutation causes an early-onset progressive action tremor, degeneration of brain stem and spinal cord neurons, and juvenile death. We cloned the vibrator mutation using an in vivo positional complementation approach and complete resequencing of the resulting 76 kb critical region from vibrator and its parental chromosome. The mutation is an intracisternal A particle retroposon insertion in...
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