Article
Naturally occurring genetic variability in expression of Gsta4 is associated with differential survival of axotomized rat motoneurons.
Neuromolecular medicine - 1 Mar 2012
Ström Mikael, Al Nimer Faiez, Lindblom Rickard, Nyengaard Jens Randel, Piehl Fredrik
Abstract excerpt
A large number of molecular pathways have been implicated in the degeneration of axotomized motoneurons. We previously have demonstrated substantial differences in the survival rate of axotomized motoneurons across different rat strains. Identification of genetic differences underlying such naturally occurring strain differences is a powerful approach, also known as forward genetics, to gain knowledge of...
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