Article
Nuclear export of the yeast hexokinase 2 protein requires the Xpo1 (Crm1)-dependent pathway.
The Journal of biological chemistry - 31 Jul 2009
Peláez Rafael, Herrero Pilar, Moreno Fernando
Abstract excerpt
Hexokinase 2 (Hxk2) from Saccharomyces cerevisiae was one of the first metabolic enzymes described as a multifunctional protein. Hxk2 has a double subcellular localization; it functions as a glycolytic enzyme in the cytoplasm and as a regulator of gene transcription of several Mig1-regulated genes in the nucleus. However, the mechanism by which Hxk2 enters and leaves the nucleus is still unknown. In low glucose...
Topics
- Active Transport, Cell Nucleus
- Amino Acids
- Cell Nucleus
- Green Fluorescent Proteins
- Hexokinase
- Karyopherins
- Mutation
- Nuclear Export Signals
- Protein Binding
- Receptors, Cytoplasmic and Nuclear
- Recombinant Fusion Proteins