Article
Divergent evolution of a Rossmann fold and identification of its oldest surviving ancestor.
International journal of bioinformatics research and applications - 1 Jan 2009
Duax William L, Huether Robert, Pletnev Vladimir, Umland Timothy C
Abstract excerpt
beta-ketoacyl (acyl carrier protein) reductase (beta-k-ACPR) enzymes are essential to fatty acid synthesis in bacteria. The analyses revealed the most primitive member of the beta-k-ACPRs family was a NADP reductase where NADP was recognised by a Thr residue in the beta2alpha3 turn. Aromatic residue stacking at the dimer interface and a previously undetected conserved sequence at the C-terminus, stabilise the...
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