Article
Patterns of divergence in homologous proteins as indicators of secondary and tertiary structure: a prediction of the structure of the catalytic domain of protein kinases.
Advances in enzyme regulation - 1 Jan 1991
Benner S A, Gerloff D
Abstract excerpt
The secondary structure and elements of tertiary structure have been predicted for the catalytic domain of protein kinases using a method that extracts structural information from the patterns of conservation and variation in an alignment of homologous proteins. The central features of this struc...
Topics
- Animals
- Base Sequence
- Binding Sites
- Genetic Variation
- Humans
- Protein Conformation
- Protein Kinases
- Sequence Homology, Nucleic Acid