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Article

A Fifth of the Protein World: Rossmann-like Proteins as an Evolutionarily Successful Structural unit.

Journal of molecular biology - 19 Feb 2021

Medvedev Kirill E, Kinch Lisa N, Dustin Schaeffer R, Pei Jimin, Grishin Nick V

Abstract excerpt

The Rossmann-like fold is the most prevalent and diversified doubly-wound superfold of ancient evolutionary origin. Rossmann-like domains are present in a variety of metabolic enzymes and are capable of binding diverse ligands. Discerning evolutionary relationships among these domains is challenging because of their diverse functions and ancient origin. We defined a minimal Rossmann-like structural motif (RLM),...

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Identifiers

PMID: 33387532
DOI: 10.1016/j.jmb.2020.166788
PMCID: PMC7870570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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