Article
Criteria for the selection of single nucleotide polymorphisms in pathway pharmacogenetics: TNF inhibitors as a case study.
Drug discovery today - 1 Sept 2009
Kooloos Wouter M, Wessels Judith A M, van der Straaten Tahar, Huizinga Tom W J, Guchelaar Henk-Jan
Abstract excerpt
Pharmacogenetics aims to identify genetic variation to predict drug response or to establish an individual optimal dose. Classically, explorative pharmacogenetic studies are performed concerning a limited number of SNPs in genes encoding enzymes involved in the drug's metabolic route. Alternatively, potential markers across the genome are elucidated by the performance of the hypothesis-free genome-wide method....
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