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Article

Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab.

Science (New York, N.Y.) - 12 Jun 2009

Aoki Scott T, Settembre Ethan C, Trask Shane D, Greenberg Harry B, Harrison Stephen C, Dormitzer Philip R

Abstract excerpt

Rotavirus outer-layer protein VP7 is a principal target of protective antibodies. Removal of free calcium ions (Ca2+) dissociates VP7 trimers into monomers, releasing VP7 from the virion, and initiates penetration-inducing conformational changes in the other outer-layer protein, VP4. We report the crystal structure at 3.4 angstrom resolution of VP7 bound with the Fab fragment of a neutralizing monoclonal...

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Share to Antibodies, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19520960
DOI: 10.1126/science.1170481
PMCID: PMC2995306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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