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Intracellular neutralisation of rotavirus by VP6-specific IgG

4 Aug 2020

Abstract excerpt

Rotavirus is a major cause of gastroenteritis in children, with infection typically inducing high levels of protective antibodies.Antibodies targeting the middle capsid protein VP6 are particularly abundant, and as VP6 is only exposed inside cells, neutralisation must be postentry.However, while a system of poly immune globulin receptor (pIgR) transcytosis has been proposed for anti-VP6 IgAs, the mechanism by...

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PMID: 32750093
DOI: 10.1371/journal.ppat.1008732

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