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Locked Nucleic Acid <i>In situ</i> Hybridization Analysis of miR-21 Expression during Colorectal Cancer Development

15 Jun 2009

Abstract excerpt

PURPOSE: To better understand microRNA miR-21 function in carcinogenesis, we analyzed miR-21 expression patterns in different stages of colorectal cancer development using in situ hybridization (ISH). EXPERIMENTAL DESIGN: Locked nucleic acid (LNA)/DNA probes and a biotin-free tyramide signal amplification system were used in ISH analyses of miRNA expression. Conditions for specific detection of miR-21 were...

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PMID: 19509156
DOI: 10.1158/1078-0432.ccr-08-3257

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