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Article

Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.

Journal of molecular biology - 31 Jul 2009

Rydberg Edwin H, Cellucci Antonella, Bartholomew Linda, Mattu Marco, Barbato Gaetano, Ludmerer Steven W, Graham Donald J, Altamura Sergio, Paonessa Giacomo, De Francesco Raffaele, Migliaccio Giovanni, Carfí Andrea

Abstract excerpt

Hepatitis C virus (HCV) exists in six major genotypes. Compared with the 1b enzyme, genotype 2b HCV polymerase exhibits a more than 100-fold reduction in sensitivity to the indole-N-acetamide class of non-nucleoside inhibitors. These compounds have been shown to bind in a pocket occupied by helix A of the mobile Lambda1 loop in the apoenzyme. The three-dimensional structure of the HCV polymerase from genotype 2b...

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PMID: 19505479
DOI: 10.1016/j.jmb.2009.06.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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