Article
Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B.
Bioorganic & medicinal chemistry letters - 15 Jan 2016
Zhang Nanjing, Turpoff Anthony, Zhang Xiaoyan, Huang Song, Liu Yalei, Almstead Neil, Njoroge F George, Gu Zhengxian, Graci Jason, Jung Stephen P, Pichardo John, Colacino Joseph, Lahser Fred, Ingravallo Paul, Weetall Marla, Nomeir Amin, Karp Gary M
Abstract excerpt
A novel series of 2-(4-sulfonamidophenyl)-indole 3-carboxamides was identified and optimized for activity against the HCV genotype 1b replicon resulting in compounds with potent and selective activity. Further evaluation of this series demonstrated potent activity across HCV genotypes 1a, 2a and 3a. Compound 4z had reduced activity against HCV genotype 1b replicons containing single mutations in the NS4B coding...
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