Article
Binding-site identification and genotypic profiling of hepatitis C virus polymerase inhibitors.
Journal of virology - 1 Jul 2007
Pauwels Frederik, Mostmans Wendy, Quirynen Ludo M M, van der Helm Liesbet, Boutton Carlo W, Rueff Anne-Stéphanie, Cleiren Erna, Raboisson Pierre, Surleraux Dominique, Nyanguile Origène, Simmen Kenneth A
Abstract excerpt
The search for hepatitis C virus polymerase inhibitors has resulted in the identification of several nonnucleoside binding pockets. The shape and nature of these binding sites differ across and even within diverse hepatitis C virus genotypes. These differences confront antiviral drug discovery with the challenge of finding compounds that are capable of inhibition in variable binding pockets. To address this, we...
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