Article
Variants of NOD1 and NOD2 genes display opposite associations with familial risk of Crohn's disease and anti-saccharomyces cerevisiae antibody levels.
Inflammatory bowel diseases - 1 Mar 2012
Vasseur Francis, Sendid Boualem, Jouault Thierry, Standaert-Vitse Annie, Dubuquoy Laurent, Francois Nadine, Gower-Rousseau Corinne, Desreumaux Pierre, Broly Franck, Vermeire Severine, Colombel Jean-Fréderic, Poulain Daniel
Abstract excerpt
BACKGROUND: NOD2 is involved in Crohn's disease (CD), but the role of NOD1 remains unclear. Anti-Saccharomyces cerevisiae antibodies (ASCA) are higher in CD patients and some of their relatives. Using family-based analyses we investigated the relationships between NOD2 mutations, NOD1 +32656 variant, and both the risk of CD and ASCA levels. We compared allelic frequencies between families with multiple CD cases...
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