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Article

Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation.

Gut - 1 Jan 2009

Takedatsu H, Taylor K D, Mei L, McGovern D P B, Landers C J, Gonsky R, Cong Y, Vasiliauskas E A, Ippoliti A, Elson C O, Rotter J I, Targan S R

Abstract excerpt

BACKGROUND AND AIMS: Genetics studies of the serum expression of antibodies to microbial antigens may yield important clues to the pathogenesis of Crohn's disease. Our aim was to conduct a linkage study using expression of anti-CBir1, anti-I2, anti-OmpC and ASCA as quantitative traits. METHODS: Expression of antibodies to microbial antigens was measured by enzyme-linked immunosorbant assay (ELISA) and a standard...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Human, Pair 4

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Identifiers

PMID: 18832525
DOI: 10.1136/gut.2008.156422
PMCID: PMC3065207

Genes

NFKB1

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