Article
Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Nov 2020
Kwon Young-Chang, Lim Jiwoo, Bang So-Young, Ha Eunji, Hwang Mi Yeong, Yoon Kyungheon, Choe Jung-Yoon, Yoo Dae-Hyun, Lee Shin-Seok, Lee Jisoo, Chung Won Tae, Kim Tae-Hwan, Sung Yoon-Kyoung, Shim Seung-Cheol, Choi Chan-Bum, Jun Jae-Bum, Kang Young Mo, Shin Jung-Min, Lee Yeon-Kyung, Cho Soo-Kyung, Kim Bong-Jo, Lee Hye-Soon, Kim Kwangwoo, Bae Sang-Cheol
Abstract excerpt
OBJECTIVE: Genome-wide association studies (GWAS) in rheumatoid arthritis (RA) have discovered over 100 RA loci, explaining patient-relevant RA pathogenesis but showing a large fraction of missing heritability. As a continuous effort, we conducted GWAS in a large Korean RA case-control population. METHODS: We newly generated genome-wide variant data in two independent Korean cohorts comprising 4068 RA cases and...
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