Article
The Drosophila hus1 gene is required for homologous recombination repair during meiosis.
Mechanisms of development - 1 Jan 2000
Peretz Gabriella, Arie Lihi Gur, Bakhrat Anna, Abdu Uri
Abstract excerpt
The checkpoint proteins, Rad9, Rad1, and Hus1 (9-1-1), form a complex which plays a central role in the DNA damage-induced checkpoint response. Previously, we demonstrated that Drosophilahus1 is essential for activation of the meiotic checkpoint elicited in double-strand DNA break (DSB) repair enzyme mutants. The hus1 mutant exhibits similar oocyte nuclear defects as those produced by mutations in these repair...
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