Article
Hsk1 kinase is required for induction of meiotic dsDNA breaks without involving checkpoint kinases in fission yeast.
Proceedings of the National Academy of Sciences of the United States of America - 23 May 2006
Ogino Keiko, Hirota Kouji, Matsumoto Seiji, Takeda Tadayuki, Ohta Kunihiro, Arai Ken-ichi, Masai Hisao
Abstract excerpt
Cdc7 kinase, conserved through evolution, is known to be essential for mitotic DNA replication. The role of Cdc7 in meiotic recombination was suggested in Saccharomyces cerevisiae, but its precise role has not been addressed. Here, we report that Hsk1, the Cdc7-related kinase in Schizosaccharomyces pombe, plays a crucial role during meiosis. In a hsk1 temperature-sensitive strain (hsk1-89), meiosis is arrested...
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