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Article

The p53-S100A2 Positive Feedback Loop Negatively Regulates Epithelialization in Cutaneous Wound Healing

26 Mar 2018

Abstract excerpt

The S100A2 protein is an important regulator of keratinocyte differentiation, but its role in wound healing remains unknown. We establish epithelial-specific S100A2 transgenic (TG) mice and study its role in wound repair using punch biopsy wounding assays. In line with the observed increase in proliferation and migration of S100A2-depleted human keratinocytes, mice expressing human S100A2 exhibit delayed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29615682
DOI: 10.1038/s41598-018-23697-5

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