Primary role of barrier dysfunction in the pathogenesis of atopic dermatitis.

Abstract excerpt

Based upon the efficacy of recently developed biologics, the pathogenesis of atopic dermatitis (AD) is being attributed once again to the prominent inflammation that occurs in this disorder. Yet, molecular genetics has clearly shown that the aetiology of AD can be attributed to mutations in stratum corneum structural proteins that impact epidermal barrier function, while inflammation instead emerges as a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Anti-Inflammatory Agents
• Share to Dermatitis, Atopic
• Share to Eczema