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Article

Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat.

Pharmacogenetics and genomics - 1 Jul 2009

Sapag Amalia, González-Martínez Ginez, Lobos-González Lorena, Encina Gonzalo, Tampier Lutske, Israel Yedy, Quintanilla María Elena

Abstract excerpt

OBJECTIVE: Alcohol is detoxified in the liver by oxidizing enzymes that require nicotinamide adenine dinucleotide (NAD+) such that, in the rat, the availability of NAD+ contributes to control voluntary ethanol intake. The UChA and UChB lines of Wistar rats drink low and high amounts of ethanol respectively and differ in the capacity of their mitochondria to oxidize NADH into NAD+. This function resides in complex...

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PMID: 19494790
DOI: 10.1097/FPC.0b013e32832dc12a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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