Article
Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection.
Hepatology (Baltimore, Md.) - 1 Sept 2009
Lei Rui Xiang, Shi Hong, Peng Xiao Mou, Zhu Yin Hong, Cheng Jie, Chen Gui Hua
Abstract excerpt
UNLABELLED: Hepatitis B e antigen (HBeAg) is a viral strategy of immune response evasion associated with hepatitis B virus (HBV) persistence. Spontaneous HBeAg seroconversion is usually accompanied by liver disease remission. Unfortunately, this goal is difficult to achieve and requires expensive and time-consuming treatment. Furin, a proprotein convertase, is involved in HBeAg maturation and is therefore a...
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